منابع مشابه
Introduction to toxicity evaluation session.
There have been invented innumerable chemical substances which enter living organisms, including humans. These may damage the liver, preserve the teeth, damage the fetus, induce cancers, cure trivial and serious diseases, destroy vermin, prolong life, increase the quality and quantity of the food supply, preserve the facade of youth for the aging and make instantaneous photographs in vibrant li...
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Precision medicine promises to transform cancer treatment in the next decade through the use of high-throughput sequencing and other technologies to identify telltale molecular aberrations that reveal therapeutic vulnerabilities of each patient’s tumor [1]. This session will address the "panomics" of cancer – the complex combination of patient-specific characteristics that drive the development...
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The field of molecular modeling has long recognized modeling the folding, assembly, and long-time dynamics of large macromolecules as its biggest challenge, since it is precisely at large size and long time scales that computational methods are most taxed. In response, many methods have been developed to reduce the computational cost by coarsening the granularity of the problem. Inevitably accu...
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Intrinsically disordered proteins (IDPs) are an important newly recognized class of proteins that rely on the lack of stable structures, both in vitro and in vivo, for function. Before the computational studies of the late 1990s, the tendency was to believe that IDPs were artifacts, resulting for example from denaturation during isolation or from the loss of critical factors such as metal ions ...
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Introduction Infections are a major cause of both human disease and loss of crop yields and animal stocks and thus cause immense damage to the worldwide economy. The significance of infectious diseases is expected to increase in an ever more connected warming world, in which new viral, bacterial and fungal pathogens can find novel hosts and ecologic niches. At the same time, the complex and sop...
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ژورنال
عنوان ژورنال: American Zoologist
سال: 1992
ISSN: 0003-1569
DOI: 10.1093/icb/32.3.448